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KMID : 0365819830230020501
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Journal of Pusan Medical College
1983 Volume.23 No. 2 p.501 ~ p.507
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An Evaluation of Computed Tomography in Intracranial Hemorrhage
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Abstract
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The author investigated lymphocytotoxic activity, peripheral absolute lymphocyte count, serum immunoglobulins and protein fractions in 122 cases of patient with various cancer and 27 cases of adult healthy control. Diagnoses were histopathologically confirmed in the paitents. The patients were consisted of 49 cases of gastric carcinoma, 10 cases of hepatocellular carcinoma. 13 cases of lung carcinoma, 10 cases of thyroid carcinoma, 12 cases of bladder carcinoma, 12 cases of endcmetrial carcinoma, and 16 cases of cervical carcinoma. Blood samples were obtained from the anterior cubital veins of the patients and control in Pusan National University Hospital during the periods from March to October, 1983. Lymphocytotoxic effect to autologous and homologous lymphocyte was estimated in sera from the patients with various cancer and control, using Terasaki´s cytotoxic test. The absolute numbers of the peripheral lymphocytes were counted by Coulter S-plus I . Serum protein fractions. were analyzed by cellulose acetate electrophoresis. Serum immunoglobulins were measured by single radial immunodiffusion method.
The results obtained were summerized as follows:
1. The sera from the patients with various cancer showed cytotoxic activity against autologous and homologous lymphocyte. However the sera from the control did not show lymphocytotoxic activity.
2. Absolute numbers of the peripheral lymphccytes were significantly reduced in the patients with various cancer when compared with control.
3. Serum IgM was more significantly increased or tended to be increased in the patients with positive lymphocytotoxity than that in the patients with negative lymphocytotoxity in hepatocellular carcinoma, thyroid carcinoma, bladder carcinoma and endcmetrial carcinoma.
4. Serum alpha-1, alpha-2 or beta-globulin were more significantly increased in the patients with positive lymphocytotoxicity than those in the patients with negative lymphocytotoxity in gastric carcinoma, lung carcinoma and cervical carcinoma.
On the basis of the results above, it is summerized that lymphocytotoxic factor may be demonst
rated in the sera of the patients with various cancer and the serum factor might belong to serum IgM, alpha- or beta-globulin fractions. The lymphocytotoxic factor demonstrated may play at, important role in reducing the absolute lymphocyte counts of peripheral blood.
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